Image-Controlled Ultrasound-Induced Drug Delivery

Sonodrugs Press Coverages:

07-02-2011 “Philips and Eindhoven University of Technology measure and visualize local chemotherapy delivery to tumors”; accompanying the publication of the successful in-vivo proof-of-concept study on MR-HIFU induced drug delivery (abstract)

18-01-2011 “‘Dancing’ bubbles tackle heart disease.” accompanying the PhD graduation of Klazina Kooiman from Erasmus Medical Center (thesis)

29-01-2009 Nanobiotix enters into collaboration with SonoDrugs consortium

28-01-2009 Philips leads European SonoDrugs project to develop image-guided localized drug delivery technologies


Sonodrugs publications:

Peer-review Journals

2013

  • ‘MRI contrast variation of thermosensitive magnetoliposomes triggered by focused ultrasound: a tool for image-guided local drug delivery.’ Lorenzato C, Cernicanu A, Meyre ME, Germain M, Pottier A, Levy L, De Senneville BD, Bos C, Moonen C, Smirnov P, Contrast Media Mol Imaging 2013, 8(2):185-192 abstract
  • ‘Observations on the viability of C6-glioma cells after sonoporation with low-intensity ultrasound and microbubbles.’ Ruijssevelt L, Smirnov P, Yudina A, Bouchaud V, Voisin P, Moonen C, IEEE Trans Ultrason Ferroelectr Freq Control 2013, 60(1):34-45 abstract
  • ‘Doxorubicin liposome-loaded microbubbles for contrast imaging and ultrasound-triggered drug delivery.’ Escoffre JM, Mannaris C, Geers B, Novell A, Lentacker I, Averkiou M, Bouakaz A, IEEE Trans Ultrason Ferroelectr Freq Control 2013, 60(1):78-87 abstract
  • ‘Microbubble attenuation and destruction: are they involved in sonoporation efficiency?’ Escoffre JM, Novell A, Piron J, Zeghimi A, Doinikov A, Bouakaz A, IEEE Trans Ultrason Ferroelectr Freq Control 2013, 60(1):46-52 abstract

2012

  • ‘Acoustical properties of individual liposome-loaded microbubbles.’ Luan Y, Faez T, Gelderblom E, Skachkov I, Geers B, Lentacker I, Van der Steen A, Versluis M, De Jong N, Ultrasound Med Biol 2012, 38(12):2174-2185 abstract
  • ‘In-vivo gene delivery by sonoporation: recent progress and prospects.’ Escoffre JM, Zeghimi A, Novell A, Bouakaz A, Curr Gene Ther 2012, ePub abstract
  • ‘Lipid-peptide vesicle nanoscale hybrids for triggered drug release by mild hyperthermia in vitro and in vivo.’ Al-Ahmady ZS, Al-Jamal WT, Bossche JV, Bui TT, Drake, AF, Mason AJ, Kostarelos K, ACS Nano 2012, 6(10):9335-9346 abstract
  • ‘Gravimetric determination of phospholipid concentration.’ Tejera-Garcia R, Connell L, Shaw WA, Kinnunen PK, Chem Phys Lipids 2012, 165(6):689-695 abstract
  • ‘Simultaneous T(1) measurements and proton resonance frequency shift based thermometry using variable flip angles.’ Hey S, de Smet M, Stehning C, Gruell H, Keupp J, Moonen CT, Ries M, Magn Reson Med 2011, 67(2):457-463 abstract
  • ‘Tumor hyperthermia and ablation in rats using a clinical MR-HIFU system equipped with a dedicated small animal setup.’ Hijnen NM, Heijman E, Köhler MO, Ylihautala M, Ehnholm GJ, Simonetti AW, Gruell H, Int J Hyperthermia 2012, 28(2):141-155 abstract
  • ‘Investigation of microbubble response to long pulses used in ultrasound-enhanced drug delivery.’ Mannaris C, Averkiou MA, Ultras Med Biol 2012, 38(4):681-691 abstract
  • ‘Pharmacokinetics & tissue distribution of temperature-sensitive liposomal doxorubicin in tumor-bearing mice triggered with mild hyperthermia.’ Al-Jamal WT, Al-Ahmady ZS, Kostarelos K, Biomaterials 2012, 33(18):4608-4617 abstract
  • ‘In vivo temperature controlled ultrasound-mediated intracellular delivery of cell-impermeable compounds.’ Yudina A, Lepetit-Coiffe M, De Smet M, Langereis S, Gruell H, Moonen CT, J Control Release 2012, 161(1):90-97 abstract
  • ‘Ultrasound-induced cell permeabilisation and hyperthermia: Strategies for local delivery of compounds with intracellular mode of action.’ Yudina A, Moonen C, Int J Hyperthermia 2012, 28(4):311-319 abstract
  • ‘Hyperthermia-triggered drug delivery from temperature-sensitive liposomes using MRI-guided high intensity focused ultrasound.’ Gruell H, Langereis S, J Control Rel 2012, 161(2):317-327 abstract
  • ‘Real-time assessment of ultrasound-mediated drug delivery using fibered confocal fluorescence microscopy.’ Derieppe M, Yudina A, Lepetit-Coiffé M, Denis de Senneville B, Bos C, Moonen C, Mol Imag Biol 2012, ePub abstract

2011

  • ‘See, reach, treat - ultrasound triggered image-guided drug delivery.’ P.G. Sanches, H. Gruell, O.C. Steinbach, Therap Deliv 2011, 2(7):919-934 abstract
  • ‘Elucidating the mechanisms behind sonoporation with adeno-associated virus-loaded microbubbles.’ Geers B, Lentacker I, Alonso A, Sanders NN, Demeester J, Meairs S, De Smedt SC, Mol Pharm 2011, 8(6):2244-2251 abstract
  • ‘Ultrasound-mediated intracellular drug delivery using microbubbles and temperature-sensitive liposomes.’ Yudina A, de Smet M, Lepetit-Coiffe M, Langereis S, Van Ruijssevelt L, Smirnov P, Bouchaud V, Voisin P, Gruell H, Moonen CT, J Control Rel 2011, 155(3):442-448 abstract
  • ‘Making unilamellar liposomes using focused ultrasound.’ Tejera-Garcia R, Ranjan, Zamotin V, Sood R, Kinnunen PK, Langmuir 2011, 27(16):10088-10097 abstract
  • ‘A fluorescent chromophore TOTO-3 as a 'smart probe' for the assessment of ultrasound-mediated local drug delivery in vivo. ’ Deckers R, Yudina A, Cardoit LC, Moonen CT, Contrast Media Mol Imaging 2011, 6(4):267-274 abstract
  • ‘Doxorubicin delivery into tumor cells with ultrasound and microbubbles.’ Escoffre JM, Piron J, Novell A, Bouakaz A, Mol Imaging Biol Mol Pharm 2011, 8(3):799-806 abstract
  • ‘Ultrasound and microbubbles for in vitro gene delivery.’ Escoffre JM, Novell A, Zeghimi A, Bouakaz A, Drug Dev Del 2011, 11:42-47 journal
  • ‘Rupture threshold characterization of polymer-shelled ultrasound contrast agents subjected to static overpressure.’ Chitnis PV, Lee P, Mamou J, Allen JS, Böhmer M, Ketterling JA, J Appl Phys 2011, 109(8):84906-84910 abstract
  • ‘Sonoporation of endothelial cells by vibrating targeted microbubbles.’ Kooiman K, Foppen-Harteveld M, der Steen AF, de Jong N, J Control Release 2011, 154(1):35-41 abstract
  • ‘Evaluation of the temporal window for drug delivery following ultrasound-mediated membrane permeability enhancement.’ Yudina A, Lepetit-Coiffe M, Moonen CT, Mol Imaging Biol 2011, 13(2):239-249 abstract
  • ‘Self-assembled liposome-loaded microbubbles: the missing link for safe and efficient ultrasound triggered drug delivery.’Geers B, Lentacker I, Sanders NN, Demeester J, Meairs S, De Smedt Sc, J Control Rel 2011, 152(2):249-56 abstract
  • ‘Magnetic resonance imaging of high intensity focused ultrasound mediated drug delivery from temperature sensitive liposomes; An in vivo proof-of-concept study.’ de Smet M, Heijman E, Langereis S, Hijnen NM, Gruell H, J Control Release 2011, 150(1)102-110 abstract
  • ‘Cardioprotective effect of calcineurin inhibition in an animal model of renal disease.’ Di Marco GS, Reuter S, Kentrup D, Ting L, Ting L, Grabner A, Jacobi AM, Pavenstadt H, Baba HA, Tiemann K, Brand M, Eur Heart J 2011 32(15):1935-1945 abstract

2010

  • ‘Vascular infarction by subcutaneous application of tissue factor targeted to tumor vessels with NGR-peptides: activity and toxicity profile.’ Dreischaluck J, Schwoppe C, Spieker T, Kessler T, Tiemann K, Liersch R, Schliemann C, Kreuter M, Kolkmeyer A, Hintelmann H, Mesters RM, Berdel WE, Int J Oncol 2010, 37(6):1389-1397 abstract
  • ‘Ultrasound triggered, image guided, local drug delivery.’ Deckers R, Moonen CT, J Control Rel 2010, 148(1):25-33 abstract
  • ‘Focused ultrasound and microbubbles for enhanced extravasation.’ Bohmer MR, Chlon CH, Raju BI, Chin CT, Shevchenko T, Klibanov AL, J Control Rel 2010, 148(1):18-24 abstract
  • ‘Indicator Dilution Models for the Quantification of Microvascular Blood Flow with Bolus Administration of Ultrasound Contrast’, Strouthos C, Lampaskis M, Averkiou M, IEEE Trans Ultrason Ferroelectr Freq Contr 2010, 57(6):1296-1310 abstract
  • ‘Temperature-sensitive liposomes for doxorubicin delivery under MRI guidance’, De Smet M, Langereis S, den Bosch SV, Gruell H, J Control Release 2010, 143(1):120-127 abstract
  • ‘Increasing the Endothelial Layer Permeability through Ultrasound-Activated Microbubbles’, Kooiman K, Emmer M, Foppen-Harteveld M, van Wamel A, de Jong N, IEEE Trans. Biomed. Eng. 2010, 57(1):29-32 abstract
  • ‘Design and evaluation of doxorubicin-containing microbubbles for ultrasound-triggered doxorubicin delivery: cytotoxicity and mechanisms involved.’, Lentacker I, Geers B, Demeester J, De Smedt SC, Sanders NN, Mol Ther 2010, 18(1):101-108 abstract
  • ‘Ultrasound triggered image guided therapy’, Moonen C, De Jong N, Steinbach O, Bohmer M, Langereis S, Medica Mundi 2010, 54:40-45 journal

2009

  • ‘Drug loaded microbubbles design for ultrasound triggered delivery’, Lentacker I, Stefaan C. De Smedt SC, Sanders NN, Soft Matter 2009, 5(11):2161-2170 abstract
  • ‘Ultrasound exposure of lipoplex loaded microbubbles facilitates direct cytoplasmic entry of the lipoplexes’, Lentacker I, Wang N, Vandenbroucke RE, Demeester J, De Smedt SC, Sanders NN, Mol Pharm 2009, 6(2):457-467 abstract
  • ‘Focused ultrasound-induced stimulation of microbubbles augments site-targeted engraftment of mesenchymal stem cells after acute myocardial infarction.’, Ghanem A, Steingen C, Brenig F, Funcke F, Bai ZY, Hall C, Chin CT, Nickenig G, Bloch W, Tiemann K, J Mol Cell Cardiol 2009, 47(3):411-418 abstract
  • ‘xxx.’ xxx



    Conferences

    2012 Sonodrugs conference April 2012 at the 12th European Symposium on Controlled Drug Delivery, Egmond aan Zee, NL

    • ‘US mediated drug delivery – an overview of the EU FP7 project Sonodrugs.’ presentation - Sio CF
    • ‘Drug painting cancer non-invasively with MRI guided High Intensity Focused Ultrasound brush: clinical perspectives.’ presentation - Wood B, invited speaker, NIH, Bethesda MD (USA)
    • ‘Nanoparticle loaded microbubbles for ultrasound mediated gene and drug delivery.’ presentation - Lentacker I, Geers B, Dewitte H, De Smedt SC
    • ‘Ultrasound-mediated drug delivery by temperature-sensitive nanocarriers under image guidance.’ presentation - Gruell H, De Smet M, Hijnen NM, Heijman E, Elevelt A, Langereis S
    • ‘Ultrasound-mediated drug and gene delivery by pressure-sensitive vehicles: summary of Sonodrugs results.’ presentation - Tiemann K, Mühlmeister M
    • ‘Modeling drug and MRI contrast agent concentrations during local drug delivery with temperature sensitive liposomes.’ poster - Ten Eikelder HMM, De Smet M, Gruell H
    • ‘Assessment of ultrasound-mediated drug delivery by real-time imaging using fibered confocal fluorescence microscopy.’ poster - Derieppe M, Yudina A, Lepetit-Coiffé M, Denis de Senneville B, Bos C, Moonen C
    • ‘Ultrasound contrast agent-mediated drug delivery in live chicken embryos.’ poster - Skachkov I, Luan Y, Van der Steen T, De Jong N, Kooiman K
    • ‘Dynamic Prf/deltaT1/T2* monitoring for the characterization of HIFU heat-induced USPIO release from thermosensitive liposomes.’ poster - Lorenzato C, Cernicanu A, Smirnov P, Denis de Senneville B, Germain M, Meyre M-E, Ries M, Moonen CTW
    • ‘MRI drug delivery evaluation with ultrasound triggered magnetoliposomes.’ poster - Lorenzato C, Cernicanu A, Meyre M-E, Germain M, Denis de Senneville B, Bos C, Moonen CTW, Smirnov P
    • ‘Viability of tumor cells upon ultrasound cavitation.’ poster - Van Ruijssevelt L, Smirnov P, Yudina A, Bouchaud V, Voisin P, Moonen CTW
    • ‘Targeted liposome-loaded microbubbles for selective ultrasound guided circulating tumor cell therapy.’ poster - Geers B, De Wever O, Mühlmeister M, Tiemann K, Bracke M, De Smedt SC, Lentacker I
    • ‘Detection of ultrasound-mediated drug delivery from liposome loaded microbubbles through in vivo optical imaging.’ poster - Cool S, Geers B, Lentacker I, Demeester J, De Smedt SC, Sanders NN
    • ‘On the effect of bubble contact and radiation force on the sonoporation efficiency.’ poster - Zeghimi A, Escoffre JM, Bouakaz A
    • ‘Blood kinetics and biodistribution of temperature sensitive liposomes for image guided drug delivery with MR-HIFU.’ poster - De Smet M, Langereis S, Hijnen NM, Heijman E, Gruell H
    • ‘Image guided HIFU-mediated local drug delivery with temperature sensitive liposomes.’ poster - Langereis S, De Smet M, Heijman E, Hijnen NM, Gruell H
    • ‘Intratumoral distribution of doxorubicin after HIFU-mediated delivery with temperature sensitive liposomes.’ poster - De Smet M, Hijnen NM, Dubois L, Lambin P, Gruell H

    2012

    • ‘Different intratumoral distributions of doxorubicin found which was released from temperature sensitive liposomes during hyperthermia, ablation and combined treatment.’ Hijnen NM, De Smet M, Heijman E, Grüll H, 3rd International Symposium for Current and Future Applications of Focused Ultrasound, Bethesda (USA), Oct 2012
    • ‘Targeted irinotecan delivery using ultrasound combined with microbubbles into subcutaneous tumors.’ Escoffre JM, Bouakaz A, IEEE International US Symposium, Dresden (DE), Oct 2012
    • ‘Ultrastructural modifications of cell membranes and organelles induced by sonoporation.’ Zeghimi A, Bouakaz A, IEEE International US Symposium, Dresden (DE), Oct 2012
    • ‘Role of thermal and mechanical effects on drug release from thermosensitive nanocarriers.’ Novell A, Escoffre JM, Al-sabbagh C, Mannaris C, Fattal E, Tsapis N, Averkiou M, Bouakaz A, IEEE International US Symposium, Dresden (DE), Oct 2012
    • ‘Targeted liposome –loaded microbubbles for elective ultrasound assisted circulating tumor cell therapy.’ Geers B, De Smedt SC, Lentacker I, World Molecular Imaging Conference 2012, Dublin (IR), Sept 2012
    • ‘Real-time imaging of doxorubicin release from thermosensitive liposomes using fibered confocal fluorescence microscopy.’ Yudina A, Derieppe M, Lorenzato C, Tejera-Garcia R, Kinnunen PKJ, Moonen C, World Molecular Imaging Conference 2012, Dublin (IR), Sept 2012
    • ‘Multimodality imaging of breast cancer bone metastases.’ Sanches P, Kaijzel E, Que I, Hoeben R, Lowik C, Gruell H, World Molecular Imaging Conference 2012, Dublin (IR), Sept 2012
    • ‘Doxorubicin liposome-loaded microbubbles for contrast imaging and ultrasound-triggered drug delivery.’ Escoffre JM, Geers B, Lentacker I, Bouakaz A, European workshop on nanomedicine in oncology, Berder Island (FR), Sept 2012
    • ‘Improved intratumoral distribution of temperature sensitive liposomes and doxorubicin after combined hyperthermia and ablation treatment.’ Hijnen NM, De Smet M, Grüll H, 11th International Congress of Hyperthermic Oncology, Kyoto (JP), Aug 2012
    • ‘Biodistribution of temperature-sensitive liposomes for MR-image guided drug delivery.’ De Smet M, Langereis S, Hijnen NM, Heijman E, Grüll H, 11th International Congress of Hyperthermic Oncology, Kyoto (JP), Aug 2012
    • ‘Ultrasound contrast agents: from imaging to therapy.’ Bouakaz A, 2nd Leeds microbubble symposium, Leeds (UK), June 2012
    • ‘Design principles of thermosensitive liposomes for local delivery of doxorubicin.’ Zamotin V, Tejera-Garcia R, Kinnunen PKJ, EuroMEMBRANE International Conference, Basel (CH), June 2012
    • ‘Irinotecan delivery by microbubble-assisted ultrasound - A pilot preclinical study.’ Escoffre JM, Novell A, Serrière S, Bouakaz A, 12th International Symposium on Therapeutic Ultrasound, Heidelberg (DE), June 2012
    • ‘The future of microbubbles in applications of therapeutic ultrasound.’ De Jong N, 12th International Symposium on Therapeutic Ultrasound, Heidelberg (DE), June 2012
    • ‘Characteristics of liposome-loaded microbubbles for therapeutic use.’ De Jong N, Luan Y, Faez T, Van der Steen T, Geers B, Dewitte H, Lentacker I, Gelderblom E, Versluis M, 12th International Symposium on Therapeutic Ultrasound, Heidelberg (DE), June 2012
    • ‘Improved intratumoral distribution of temperature sensitive liposomes and doxorubicin after combined hyperthermia and ablation treatment.’ Hijnen NM, De Smet M, Gruell H, 12th International Symposium on Therapeutic Ultrasound, Heidelberg (DE), June 2012
    • ‘Ultrasound-mediated gene delivery to skeletal muscles in vivo.’ P. Sanches, M. Mühlmeister, K. Tiemann, H. Grüll, 12th International Symposium on Therapeutic Ultrasound, Heidelberg (DE), June 2012
    • ‘Optimization of saturation pulse length in parallel transmission based amide proton transfer MRI for oncology applications.’ J. Keupp, ISMRM, Melbourne (AUS), May 2012
    • ‘Rapid dynamic PRF/deltaT1/T2* monitoring for the characterization of heat-induced USPIO release from thermosensitive liposomes.’ Lorenzato C, Cernicanu A, Smirnov P, Denis de Senneville B, Germain M, Meyre M-E, Ries M, Moonen C, ISMRM, Melbourne (AUS), May 2012
    • ‘Ultrasound mediated targeted delivery: in vitro evaluation and preclinical validation.’ Escoffre J-M, Novell A, Serrière S, Bouakaz A, Congress of Physiology, Pharmacology and Therapeutics, Dijon (FR), April 2012
    • ‘Intratumoral distribution of doxorubicin after HIFU-mediated delivery with temperature sensitive liposomes.’ De Smet M, Hijnen NM, Dubois L, Lambin P, Gruell H, Biomedica Life Science Summit, Liege (BE), April 2012
    • ‘Self-assembled leucine zipper peptide-lipid hybrid vesicles for the engineering of temperature-responsive doxorubicin-loaded liposomes.’ Al-Ahmady ZS, Al-Jamal WT, Bui TT, Drake AF, Mason J, Bossche JV, Kostarelos K, 243th American Chemical Society national meeting, San Diego (USA), March 2012
    • ‘Coiled-coil leucine zipper peptides anchored onto lipid bilayers for the design of temperature-sensitive liposomes.’ Al-Ahmady ZS, Al-Jamal WT, Bui TT, Drake AF, Mason J, Bossche JV, Kostarelos K, 243th American Chemical Society national meeting, San Diego (USA), March 2012
    • ‘Thermosensitive liposomal doxorubicin and tumor hyperthermia: matching the heating protocol with the liposome system.’ Al-Jamal WT, Al-Ahmady ZS, Kostarelos K, 243th American Chemical Society national meeting, San Diego (USA), March 2012
    • ‘High-speed fluorescence imaging of the US-triggered release from liposome-loaded microbubbles.’ Gelderblom E, Luan Y, Dewitte H, Geers B, Lentacker I, Van der Steen T, De Jong N, Versluis M, 17th European symposium on ultrasound contrast imaging, Rotterdam (NL), Jan 2012
    • ‘Enhanced gene and drug delivery with ultrasound and microbubbles.’ Bouakaz A, Escoffre J-M, Novell A, Zeghimi A, 17th European symposium on ultrasound contrast imaging, Rotterdam (NL), Jan 2012
    • ‘Ultrasound-induced temperature elevation for in-vitro controlled release of thermosensitive liposomes.’ Mannaris C, Escoffre J-M, Bouakaz A, Meyre M-E, Germain M, Averkiou MA, 17th European symposium on ultrasound contrast imaging, Rotterdam (NL), Jan 2012
    • ‘Ultrasound-assisted doxorubicin delivery using doxorubicin-liposomes loaded microbubbles.’ Escoffre JM, Novell A, Geers B, Lentacker I, Bouakaz A, 17th European symposium on ultrasound contrast imaging, Rotterdam (NL), Jan 2012
    • ‘Targeted liposome-loaded microbubbles to detect and selectively destroy metastasis cells.’ Geers B, Mühlmeister M, De Wever O, Tiemann K, Bracke M, De Smedt SC, Lentacker I, 17th European symposium on ultrasound contrast imaging, Rotterdam (NL), Jan 2012

    2011

    • ‘Ultrasound-induced temperature elevation for in-vitro controlled release of thermo-sensitive liposomes.’ Mannaris C, Efthymiou E, Meyre M-E, Rio L, Germain M, Pottier A, Levy L, Averkiou MA, 162nd Meeting of the Acoustical Society of America, San Diego (USA), Oct-Nov 2011
    • ‘Sonoporation of endothelial cells in vivo.’ Skachkov I, Kooiman K, Luan Y, van der Steen T, de Jong N, IEEE International Ultrasonics Symposium, Orlando (USA), Oct 2011
    • ‘Optical characterization of individual liposome loaded microbubbles.’ Luan Y, Faez T, Gelderblom EC, Skachkov I, Geers B, Lentacker I, van der Steen AFW, Versluis M, de Jong N,IEEE International Ultrasonics Symposium, Orlando (USA), Oct 2011
    • ‘Doxorubicin-liposomes loaded microbubbles for ultrasound-triggered doxorubicin delivery.’ Escoffre JM, Geers B, Lentacker I, Bouakaz A, IEEE International Ultrasonics Symposium, Orlando (USA), Oct 2011
    • ‘In-vitro evaluation of thermosensitive liposomes for high-intensity focused ultrasound-triggered doxorubicin delivery .’ Escoffre JM, Mannaris C, Efthymiou E, Novell A, Meyre M-E, Germain M, Averkiou M, Bouakaz A, IEEE International Ultrasonics Symposium, Orlando (USA), oct 2011
    • ‘Progress in image guided ultrasound mediated drug delivery in the European Union project Sonodrugs.’ Sio CF, ICUS Bubble conference, Chicago, Sept 2011
    • ‘Focused ultrasound mediated drug delivery in vitro and in vivo and the influence of short and long pulsing schemes on delivery efficacy. ’ Muehlmeister M, Tenbrinck D, McFarland RJ, McKeown KR, Matsunaga TO, Stypmann J, Seip R, Raju, BI, Tiemann K, World Moleculear Imaging Conference, San Diego (US), Sept 2011
    • ‘Temperature-controlled ultrasound-mediated intracellular delivery of cell-impermeant molecules: in vivo study. ’ Yudina A, Lepetit-Coiffe M, de Smet M, Langereis S, Lorenzato C, Gruell H, Moonen C, World Molecular Imaging Conference, San Diego (US), Sept 2011
    • ‘In vivo gene transfection mediated by focused ultrasound.’ Sanches P, Bohmer M, Tiemann K, Gruell H, World Molecular Imaging Conference, San Diego (US), Sept 2011
    • ‘Ultrasound mediated membrane permeability enhancement of C6 glioma cells: a preliminary viability study for evaluation of local drug delivery. ’ Van Ruijssevelt L, Smirnov P, Yudina A, Bouchaud V, Voisin P, Moonen C, World Molecular Imaging Conference, San Diego (US), Sept 2011
    • ‘Fabrication, Characterisation and Translational Applications.’ Lentacker I, Geers B, de Smedt SC, Muehlmeister M, Tiemann K, Luan Y, De Jong N, Bohmer M, Vulto S, Sio CF, First Annual Microbubble Symposium of the University of Leeds Microbubble Consortium, Leeds, July 2011
    • ‘A novel method to determine the lipid viscosity and distribution of coated microbubbles.’ Kooiman K, Emmer M, Kokhuis TJA, Bosch JG, de Gruiter HM, van Royen ME, van Cappellen WA, Houtsmuller AB, van der Steen AFW, de Jong N, First Annual Microbubble Symposium of the University of Leeds Microbubble Consortium, Leeds, July 2011
    • ‘Assessment of Ultrasound-Mediated Drug Delivery by Real-Time Imaging Using Fibered Confocal Fluorescence Microscopy.’ Derieppe M, Lepetit-Coiffé M, Yudina A, Denis de Senneville B, Roujol S, Moonen CTW, 6th European Molecular Imaging Meeting 2011 (EMIM ESMI), Leiden, NL, June 2011.
    • ‘Real-Time Imaging of 2-step Ultrasound-Mediated Temperature-Controlled Drug Delivery using Fibered Confocal Fluorescence Microscopy.’ Yudina A, Lepetit-Coiffe M, Derieppe M, de Smet M, Langereis S, Gruell H, Moonen C, 6th European Molecular Imaging Meeting 2011 (EMIM ESMI), Leiden, NL, June 2011.
    • ‘MR monitoring of HIFU-mediated local drug delivery with temperature sensitive liposomes.’ de Smet M, Langereis S, Heijman E, Hijnen N, Gruell H, 6th European Molecular Imaging Meeting 2011 (EMIM ESMI), Leiden, NL, June 2011
    • ‘Use of high intensity focused ultrasound for localized activation of thermosensitive liposomes for drug delivery.’ Mannaris C, Efthymiou E, Khokhlova VA, Ilin SA, Escoffre JM, Bouakaz A, Mathieu G, Averkiou MA, 161st Meeting of the Acoustical Society of America, Seattle, USA, May 2011.
    • ‘Investigation of microbubble response to long ultrasonic pulses used in therapeutic applications.’ Mannaris C, Averkiou M, 161st Meeting of the Acoustical Society of America, Seattle, USA, May 2011.
    • ‘Temperature-Induced Drug Delivery Using MR-Guided High Intensity Focused Ultrasound.’ Langereis S, de Smet M, Heijman E, Hijnen N, H. Gruell H, 28th Annual Meeting of the Society for Thermal Medicine, New Orleans, USA, May 2011.
    • ‘HIFU-mediated local drug delivery under MR image guidance.’ de Smet M, Langereis S, Heijman E, Hijnen N, Gruell H, esho 2011 - 27h Annual Meeting of the European society for hyperthermic oncology, Arhus, DK, May 2011.
    • ‘Thermosensitive magnetoliposomes for MRI-guided drug delivery.’ Meyre ME, Lorenzato C, Germain M, Smirnov P, Moonen C, Pottier A, Levy L, 4th European-Conference for Clinical Nanomedicine, Basel, CH, May 2011.
    • ‘Parallel RF transmit based MRI technique for highly sensitive detection of Amide Proton Transfer in the human brain at 3T.’ Keupp J et al., ISMRM 2011, Montreal, CA, May 2011.
    • ‘High-intensity focused ultrasound-mediated doxorubicin delivery with thermosensitive liposomes.’ Escoffre JM, Mannaris C, Rio L, Meyre ME, Germain M, Averkiou M, Bouakaz A, International Symposium on Therapeutic Ultrasound, New York, USA, April 2011.
    • ‘Self-assembled liposome loaded microbubbles.’Geers B, Lentacker I, Sanders NN, Demeester J, Meairs S, De Smedt SC, International Symposium on Therapeutic Ultrasound, New York, USA, April 2011.
    • ‘Near-Field Heating of Volumetric MR-HIFU Hyperthermia.’ Kohler M; Mougenot C; Ylihautala M, International Symposium on Therapeutic Ultrasound, New York, USA, April 2011.
    • ‘Temperature-induced drug delivery under MR image guidance.’ de Smet M, Heijman E, Langereis S, Hijnen N, Gruell H, ISMRM Benelux, Jan 2011.
    • ‘MRI-guided HIFU-mediated drug delivery to tumors with temperature-sensitive liposomes; de Smet M, S. Langereis S, E. Heijman E, Hijnen NM, Gruell H, TOPIM 2011, Les Houches, FR, Jan 2011.
    • ‘Ultrasound induced drug delivery.’ Gruell H, TOPIM 2011, Les Houches, FR, Jan 2011.
    • ‘Focused Ultrasound Induced Extravasation: In vivo SPECT/CT Imaging and Quantification.’ Sanches P, Rossin R, Bohmer M, Tiemann K, Gruell H, TOPIM 2011, Les Houches, FR, Jan 2011.
    • ‘Mechanisms of sonoporation.’ Lentacker I., Geers B., De Smedt S.C., 16th European Symposium on Ultrasound Contrast Imaging, Rotterdam (NL), Jan. 2011.
    • ‘self-assemblED liposome-loaded microbubbles: the missing link for safe and efficient ultrasound triggered drug-delivery.’ Geers B, Lentacker I, Sanders N, Demeester J, Meairs S, De Smedt S, 16th European Symposium on Ultrasound Contrast Imaging, Rotterdam (NL), Jan. 2011.
    • ‘Microbubble destruction: A key step for gene delivery with sonoporation.’ Escoffre JM, Zeghimi A, Novell A, Bouakaz A, 16th European Symposium on Ultrasound Contrast Imaging, Rotterdam (NL), Jan. 2011.
    • ‘Optical Characterization of Individual Liposome Loaded Microbubbles.’ Y. Luan, 16th European Symposium on Ultrasound Contrast Imaging, Rotterdam (NL), Jan. 2011.

    2010

    • ‘Design principles of thermosensitive liposomes for MRI guided HIFU triggered anti-cancer drug delivery.’ Tejera-Garcia R, Zamotin V, Kinnunen PKJ, MRgFUS symposium, Oct 2010, Virginia, USA
    • ‘Temperature sensitive liposomes for ultrasound-induced drug delivery under MRI guidance: in vitro and in vivo results.’ Heijman E, de Smet M, Hijnen N, Langereis S, Gruell, MRgFUS symposium, Oct 2010, Virginia, USA
    • ‘Focused Ultrasound Mediated Targeted Drug Delivery.’ Moonnen C, MRgFUS symposium, Oct 2010, Virginia, USA
    • ‘Image Guided Ultrasound mediated Drug Delivery: Sonodrugs Update.’ Seip R, Bohmer M, Gruell H, Steinbach O, Vulto S, ICUS Bubble conference, Chicago, Sept 2010
    • ‘Ultrasound-mediated drug delivery: evaluate correspondence of macroscopic fluorescence imaging patern with acoustical properties of the transducer.’ Lepetit-Coiffe M, Yudina A, Poujol C, Lourenco de Oliveira P, Couillaud F, Moonen CTW, World Molecular Imaging Conference, Kyoto (JP), sep 2010
    • ‘Long-lasting effect of ultrasound on cell membrane permeability: application to 2-step intracellular small-molecule delivery system using thermosensitive liposomes and cavitation’, Yudina A, Lepetit-Coiffe M, de Smet M, Langereis S, Gruell H, Moonen C, World Molecular Imaging Conference, Kyoto (JP), sep 2010
    • ‘Temperature sensitive Liposomes for Ultrasound-induced Drug Delivery under MRI Guidance’, Gruell H, de Smet M, Hijnen N, Heijman E, Keupp J, Langereis S, World Molecular Imaging Conference, Kyoto (JP), sep 2010
    • ‘In Vivo SPECT/CT Imaging of Focused Ultrasound Induced Extravasation’, Gruell H, Sanches, P Rossin R, Bohmer M, Tiemann K, World Molecular Imaging Conference, Kyoto (JP), sep 2010
    • ‘Controlled Drug Delivery under Image Guidance’, Gruell H, 5th European Molecular Imaging Meeting, Warsaw, (PL), May 2010.
    • ‘Evaluation of the Temporal Window for Drug Delivery Following Ultrasound Mediated Membrane Permeability Enhancement’, Yudina A, Lepetit-Coiffé M, Moonen CTW, 15th European Molecular Imaging Meeting, Warsaw, (PL), May 2010.
    • ‘Focused Ultrasound and microbubbles for enhanced extravasation’, Bohmer MR, Chlon CHT, Raju BI, Chin CT, Shevchenko T, Klibanov A, 11th European symposum on controlled drug delivery, Egmond-aan-zee (NL), April 2010.
    • ‘Adeno-associated virus loaded microbubbles as a tool for targeted gene delivery’, Geers B, Lentacker I, Alonso A, Meairs S, Demeester J, De Smedt SC, Sanders NN, 11th European symposum on controlled drug delivery, Egmond-aan-zee (NL), April 2010.
    • ‘Ultrasound responsive doxorubicin-loaded microbubbles; towards an easy applicable drug delivery platform’, Geers B, Lentacker I, Cool S, Demeester J, Stefaan C. De Smedt, Niek N. Sanders, 11th European symposum on controlled drug delivery, Egmond-aan-zee (NL), April 2010.
    • ‘Tumor Cell killing efficiency of doxorubicin loaded microbubbles after ultrasound exposure’, Lentacker I, Geers B, Demeester J, De Smedt SC, Sanders NN, 11th European symposum on controlled drug delivery, Egmond-aan-zee (NL), April 2010.
    • ‘HIFU-mediated doxorubicin release from temperature-sensitive liposomes under MRI guidance’, de Smet M, Langereis S, v.d. Molengraaf R, Heijman E, Hijnen N, Gruell H, Biomedica2010 Summit, Aachen (DE), March 2010
    • ‘Quantification of Ultrasound-mediated Local Drug Delivery with Nuclear Techniques;, Sanches P, Rossin R, Bohmer M, Tiemann K, Nicolaij K, Gruell H, Biomedica2010 Summit, Aachen (DE), March 2010.
    • ‘Temperature sensitive liposomes for drug delivery with MRI-HIFU’, de Smet M, Langereis S, van de Molengraaf R, Heijman E, Hijnen N, Gruell H, 2nd Annual Meeting of the ISMRM Benelux, Utrecht (NL), Jan. 2010.
    • ‘SPECT/CT Imaging and Quantification of Focused Ultrasound Induced Extravasation’, Sanchez P, Rossin R, Bohmer M, Tiemann K, Grull H, 15th European Symposium on Ultrasound Contrast Imaging, Rotterdam (NL), Jan. 2010.
    • ‘Experimental investigation of microbubble response to ultrasonic pulses used in therapeutic applications’, Mannaris C, Stylianou K, de Jong N, Averkiou M, 15th European Symposium on Ultrasound Contrast Imaging, Rotterdam (NL), Jan. 2010.
    • ‘Tumor cell killing efficiency of doxorubicin-liposome loaded microbubbles after ultrasound exposure’, Lentacker I, Geers B, Demeester J, De Smedt SC, Sanders NN, 15th European Symposium on Ultrasound Contrast Imaging, Rotterdam (NL), Jan. 2010.
    • ‘Drug uptake by endothelial cells through targeted microbubble sonoporation’, Kooiman K, Foppen-Harteveld M, de Jong N, 15th European Symposium on Ultrasound Contrast Imaging, Rotterdam (NL), Jan. 2010.
    • ‘Enhancement of doxorubicin effect on cancer cell mortality with ultrasound and microbubbles’, Piron J, Novell A, Kaddur K, Bouakaz A, 15th European Symposium on Ultrasound Contrast Imaging, Rotterdam (NL), Jan. 2010.

    2009

    • ‘Quantitative imaging of the US-mediated uptake of the intercalating probes by the tumor cells’, Yudina A, Lepetit-Coiffe M, Lourenco de Oliveira P, Deckers R, Couillaud F, Moonen CTW, World Molecular Imaging Conference, Montreal (CA), sep 2009
    • ‘TOTO-3 as a smart probe for the assesment of ultrasound-mediated local drug delivery in vivo’, Yudina A, Deckers R, Debeissat C, Moonen CTW, World Molecular Imaging Conference, Montreal (CA), sep 2009
    • ‘Temperature-controlled US-mediated intracellular delivery of a fluorescent cell-impermeant model drug using temperature sensitive liposomes and cavitation’, de Smet M, Yudina A, Lepetit-Coiffe M, Langereis S, Deckers R, Grull H, Moonen C, World Molecular Imaging Conference, Montreal (CA), sep 2009
    • ‘Magnetic Resonance-guided Imaging of Temperature Induced Drug Delivery’, Langereis S, de Smet M, Keupp J, Heijman E, Gruell H, World Molecular Imaging Conference, Montreal (CA), sep 2009
    • ‘Binding force of targeted microbubbles measured by ultrasound radiation force’, Sugiura T, Kooiman K, Emmer M, Vos HJ, de Jong N, van Wamel A, World Molecular Imaging Conference, Montreal (CA), sep 2009
    • ‘Sonoporation induced drug uptake by endothelial cells with ultrasound and CD31-targeted microbubbles’, Kooiman K, Foppen-Harteveld M, de Jong N, World Molecular Imaging Conference, Montreal (CA), sep 2009
    • ‘Correlation of ultrasound-mediated drug delivery with acoustical properties of the transducer by macroscopic fluorescence imaging’, Lepetit-Coiffe M, Yudina A, Lourenco de Oliveira P, Decker R, Couillaud F, Moonen CTW,ISTU, Aix-en-Provence (FR), sep 2009
    • ‘Enhancement of doxorubicin effect on cancer cell mortality with ultrasound and microbubbles’, Piron J, Kaddur K, Bouakaz A, ISTU, Aix-en-Provence (FR), sep 2009

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