Sonodrugs Press Coverages:

07-02-2011 Philips and Eindhoven University of Technology measure and visualize local chemotherapy delivery to tumors.

18-01-2011 Hartkwalen te lijf met ‘dansende’ bellen.

29-01-2009 Nanobiotix enters into collaboration with ‘SonoDrugs’ consortium

28-01-2009 Philips leads European ‘SonoDrugs’ project to develop image-guided localized drug delivery technologies

Sonodrugs publications:

Journals

‘Elucidating the Mechanisms Behind Sonoporation with Adeno-Associated Virus-Loaded Microbubbles.’ Geers B, Lentacker I, Alonso A, Sanders NN, Demeester J, Meairs S, De Smedt SC, Mol Pharm, 2011, Nov 4 [Epub ahead of print] abstract
‘Simultaneous T(1) measurements and proton resonance frequency shift based thermometry using variable flip angles. ’ Hey S, de Smet M, Stehning C, Gruell H, Keupp J, Moonen CT, Ries M, Magn Reson Med 2011, Nov 2 [Epub ahead of print] abstract
‘Ultrasound-mediated intracellular drug delivery using microbubbles and temperature-sensitive liposomes.’ Yudina A, de Smet M, Lepetit-Coiffe M, Langereis S, Van Ruijssevelt L, Smirnov P, Bouchaud V, Voisin P, Gruell H, Moonen CT, J Control Rel, 2011, 155, 442-448. abstract
‘Making unilamellar liposomes using focused ultrasound; Tejera-Garcia R, Ranjan, Zamotin V, Sood R, Kinnunen PK, Langmuir 2011, 27, 10088-10097. abstract
‘Rupture threshold characterization of polymer-shelled ultrasound contrast agents subjected to static overpressure.’ Chitnis PV, Lee P, Mamou J, Allen JS, Bohmer M, Ketterling JA, J Appl Phys. 2011, 109, 84906-8490610. abstract
‘A fluorescent chromophore TOTO-3 as a 'smart probe' for the assessment of ultrasound-mediated local drug delivery in vivo. ’ Deckers R, Yudina A, Cardoit LC, Moonen CT, Contrast Media Mol Imaging. 2011, 6, 267-274 abstract
‘Doxorubicin delivery into tumor cells with ultrasound and microbubbles.’ Escoffre JM, Piron J, Novell A, Bouakaz A, Mol Imaging Biol. Mol Pharm. 2011, 8, 799-806. abstract
‘Ultrasound & microbubbles for in vitro gene delivery. ’ Escoffre JM, Novell A, Zeghimi A, Bouakaz A, Drug Dev. Del. 2011, 11, 42-47
‘Rupture threshold characterization of polymer-shelled ultrasound contrast agents subjected to static overpressure.’ Chitnis PV, Lee P, Mamou J, Allen JS, Bohmer M, Ketterling JA, J Appl Phys. 2011, 109, 84906-8490610. abstract
‘Evaluation of the Temporal Window for Drug Delivery Following Ultrasound-Mediated Membrane Permeability Enhancement.’ Yudina A, Lepetit-Coiffe M, Moonen CT, Mol Imaging Biol. Mol Imaging Biol. 2011, 13, 239-49. abstract
‘Self-assembled liposome-loaded microbubbles: the missing link for safe and efficient ultrasound triggered drug delivery.’Geers B, Lentacker I, Sanders NN, Demeester J, Meairs S, De Smedt Sc, J Control Rel. 2011, 152, 249-56 abstract
‘Magnetic resonance imaging of high intensity focused ultrasound mediated drug delivery from temperature sensitive liposomes; An in vivo proof-of-concept study. ’ de Smet M, Heijman E, Langereis S, Hijnen N, Gruell H, J Control Release. 2011, 150, 102-110. abstract
‘Cardioprotective effect of calcineurin inhibition in an animal model of renal disease.’ Di Marco GS, Reuter S, Kentrup D, Ting L, Ting L, Grabner A, Jacobi AM, Pavenstadt H, Baba HA, Tiemann K, Brand M, Eur Heart J. 2010 Dec 7. [Epub ahead of print]. abstract
‘Vascular infarction by subcutaneous application of tissue factor targeted to tumor vessels with NGR-peptides: activity and toxicity profile.’ Dreischaluck J, Schwoppe C, Spieker T, Kessler T, Tiemann K, Liersch R, Schliemann C, Kreuter M, Kolkmeyer A, Hintelmann H, Mesters RM, Berdel WE. Int J Oncol. 2010, 37, 1389-97. abstract
‘Ultrasound triggered, image guided, local drug delivery.’ Deckers R, Moonen CT, J. Controlled Rel., 2010, 148, 25-33. abstract
‘Focused ultrasound and microbubbles for enhanced extravasation.’ Bohmer MR, Chlon CH, Raju BI, Chin CT, Shevchenko T, Klibanov AL., J Control Rel. 2010, 148, 18-24 abstract
‘Indicator Dilution Models for the Quantification of Microvascular Blood Flow with Bolus Administration of Ultrasound Contrast’, Strouthos C, Lampaskis M, Averkiou M, IEEE Trans Ultrason Ferroelectr Freq Contr 2010, 57, 1296-310. abstract
‘Temperature-sensitive liposomes for doxorubicin delivery under MRI guidance’, de Smet M, Langereis S, den Bosch SV, Gruell H, J Control Release, 2010, 143, 120-7. abstract
‘Increasing the Endothelial Layer Permeability through Ultrasound-Activated Microbubbles’, Kooiman K, Emmer M, Foppen-Harteveld M, van Wamel A, de Jong N, IEEE Trans. Biomed. Eng. 2010, 57, 29-32. abstract
‘Design and Evaluation of Doxorubicin-containing Microbubbles for Ultrasound-triggered Doxorubicin Delivery: Cytotoxicity and Mechanisms Involved.’, Lentacker I, Geers B, Demeester J, De Smedt SC, Sanders NN., Mol Ther. 2010, 18, 101-108. abstract
‘Ultrasound triggered image guided therapy’, Bohmer M, Moonen C, de Jong N, Langereis S, Steinbach O, MEDICAMUNDI, 2010, 54, 40. journal
‘Drug loaded microbubbles design for ultrasound triggered delivery’ Lentacker I, Stefaan C. De Smedt SC, Sanders NN, Soft Matter 2009, 5, 2161-2170.
‘Ultrasound exposure of lipoplex loaded microbubbles facilitates direct cytoplasmic entry of the lipoplexes’, Lentacker I, Wang N, Vandenbroucke RE, Demeester J, De Smedt SC, Sanders NN, Mol. Pharm. 2009, 6, 457-467. abstract
‘Focused ultrasound-induced stimulation of microbubbles augments site-targeted engraftment of mesenchymal stem cells after acute myocardial infarction.’, Ghanem A, Steingen C, Brenig F, Funcke F, Bai ZY, Hall C, Chin CT, Nickenig G, Bloch W, Tiemann K, J Mol Cell Cardiol. 2009, 47, 411-8. abstract

Conferences

‘Sonoporation of endothelial cells in vivo.’ Skachkov I, Kooiman K, Luan Y, van der Steen T, de Jong N, IEEE International Ultrasonics Symposium, Orlando (USA), Oct 2011
‘Optical characterization of individual liposome loaded microbubbles.’ Luan Y, Faez T, Gelderblom EC, Skachkov I, Geers B, Lentacker I, van der Steen AFW, Versluis M, de Jong N,IEEE International Ultrasonics Symposium, Orlando (USA), Oct 2011
‘Doxorubicin-liposomes loaded microbubbles for ultrasound-triggered doxorubicin delivery.’ Escoffre JM, Geers B, Lentacker I, Bouakaz A, IEEE International Ultrasonics Symposium, Orlando (USA), Oct 2011
‘In-vitro evaluation of thermosensitive liposomes for high-intensity focused ultrasound-triggered doxorubicin delivery .’ Escoffre JM, Mannaris C, Efthymiou E, Novell A, Meyre M-E, Germain M, Averkiou M, Bouakaz A, IEEE International Ultrasonics Symposium, Orlando (USA), oct 2011
‘Progress in image guided ultrasound mediated drug delivery in the European Union project Sonodrugs.’ Sio SF, ICUS Bubble conference, Chicago, Sept 2011
‘Focused ultrasound mediated drug delivery in vitro and in vivo and the influence of short and long pulsing schemes on delivery efficacy. ’ Muehlmeister M, Tenbrinck D, McFarland RJ, McKeown KR, Matsunaga TO, Stypmann J, Seip R, Raju, BI, Tiemann K, World Moleculear Imaging Conference, San Diego (US), Sept 2011
‘Temperature-controlled ultrasound-mediated intracellular delivery of cell-impermeant molecules: in vivo study. ’ Yudina A, Lepetit-Coiffe M, de Smet M, Langereis S, Lorenzato C, Gruell H, Moonen C, World Molecular Imaging Conference, San Diego (US), Sept 2011
‘In vivo gene transfection mediated by focused ultrasound.’ Sanches P, Bohmer M, Tiemann K, Gruell H, World Molecular Imaging Conference, San Diego (US), Sept 2011
‘Ultrasound mediated membrane permeability enhancement of C6 glioma cells: a preliminary viability study for evaluation of local drug delivery. ’ Van Ruijssevelt L, Smirnov P, Yudina A, Bouchaud V, Voisin P, Moonen C, World Molecular Imaging Conference, San Diego (US), Sept 2011
‘Fabrication, Characterisation and Translational Applications.’ Lentacker I, Geers B, de Smedt SC, Muehlmeister M, Tiemann K, Luan Y, De Jong N, Bohmer M, Vulto S, Sio CF, First Annual Microbubble Symposium of the University of Leeds Microbubble Consortium, Leeds, July 2011
‘A novel method to determine the lipid viscosity and distribution of coated microbubbles.’ Kooiman K, Emmer M, Kokhuis TJA, Bosch JG, de Gruiter HM, van Royen ME, van Cappellen WA, Houtsmuller AB, van der Steen AFW, de Jong N, First Annual Microbubble Symposium of the University of Leeds Microbubble Consortium, Leeds, July 2011
‘Assessment of Ultrasound-Mediated Drug Delivery by Real-Time Imaging Using Fibered Confocal Fluorescence Microscopy.’ Derieppe M, Lepetit-Coiffe M, Yudina A, Denis de Senneville B, Roujol S, Moonen CTW, 6th European Molecular Imaging Meeting 2011 (EMIM ESMI), Leiden, NL, June 2011.
‘Real-Time Imaging of 2-step Ultrasound-Mediated Temperature-Controlled Drug Delivery using Fibered Confocal Fluorescence Microscopy.’ Yudina A, Lepetit-Coiffe M, Derieppe M, de Smet M, Langereis S, Gruell H, Moonen C, 6th European Molecular Imaging Meeting 2011 (EMIM ESMI), Leiden, NL, June 2011.
‘MR monitoring of HIFU-mediated local drug delivery with temperature sensitive liposomes.’ de Smet M, Langereis S, Heijman E, Hijnen N, Gruell H, 6th European Molecular Imaging Meeting 2011 (EMIM ESMI), Leiden, NL, June 2011
‘Use of high intensity focused ultrasound for localized activation of thermosensitive liposomes for drug delivery.’ Mannaris C, Efthymiou E, Khokhlova VA, Ilin SA, Escoffre JM, Bouakaz A, Mathieu G, Averkiou MA, 161st Meeting of the Acoustical Society of America, Seattle, USA, May 2011.
‘Investigation of microbubble response to long ultrasonic pulses used in therapeutic applications.’ Mannaris C, Averkiou M, 161st Meeting of the Acoustical Society of America, Seattle, USA, May 2011.
‘Temperature-Induced Drug Delivery Using MR-Guided High Intensity Focused Ultrasound.’ Langereis S, de Smet M, Heijman E, Hijnen N, H. Gruell H, 28th Annual Meeting of the Society for Thermal Medicine, New Orleans, USA, May 2011.
‘HIFU-mediated local drug delivery under MR image guidance.’ de Smet M, Langereis S, Heijman E, Hijnen N, Gruell H, esho 2011 - 27h Annual Meeting of the European society for hyperthermic oncology, Arhus, DK, May 2011.
‘Thermosensitive magnetoliposomes for MRI-guided drug delivery.’ Meyre ME, Lorenzato C, Germain M, Smirnov P, Moonen C, Pottier A, Levy L, 4th European-Conference for Clinical Nanomedicine, Basel, CH, May 2011.
‘Parallel RF transmit based MRI technique for highly sensitive detection of Amide Proton Transfer in the human brain at 3T.’ Keupp J et al., ISMRM 2011, Montreal, CA, May 2011.
‘Temperature-induced drug delivery using MR-guided high intensity focused ultrasound.’ Langereis S, de Smet M, Heijman E, Hijnen N, Gruell H, 28th Annual Meeting of the Society for Thermal Medicine, New Orleans (USA), May 2011.
‘Local drug delivery with temperature senstive liposomes under MR image guidance.’ de Smet M, Langereis S, Heijman E, Hijnen NM, Gruell H, Biomedica2011 Summit, Eindhoven (NL), April 2011.
‘Ultrasound drug delivery: in vivo SPECT/CT imaging and quantification.’ Sanches P, Gruell H, Biomedica2011 Summit, Eindhoven (NL), April 2011.
‘High-intensity focused ultrasound-mediated doxorubicin delivery with thermosensitive liposomes.’ Escoffre JM, Mannaris C, Rio L, Meyre ME, Germain M, Averkiou M, Bouakaz A, International Symposium on Therapeutic Ultrasound, New York, USA, April 2011.
‘Self-assembled liposome loaded microbubbles.’Geers B, Lentacker I, Sanders NN, Demeester J, Meairs S, De Smedt SC, International Symposium on Therapeutic Ultrasound, New York, USA, April 2011.
‘Near-Field Heating of Volumetric MR-HIFU Hyperthermia.’ Kohler M; Mougenot C; Ylihautala M, International Symposium on Therapeutic Ultrasound, New York, USA, April 2011.
‘The use of contrast agents in cancer immunotherapy: the use of mRNA loaded microbubbles for transfection of dendritic cells.’ Dewitte H, De Temmerman M, De Smedt SC, Rejman J, Lentacker I, International Symposium on Therapeutic Ultrasound, New York, USA, April 2011.
‘Temperature-induced drug delivery under MR image guidance.’ de Smet M, Heijman E, Langereis S, Hijnen N, Gruell H, ISMRM Benelux, Jan 2011.
‘MRI-guided HIFU-mediated drug delivery to tumors with temperature-sensitive liposomes; de Smet M, S. Langereis S, E. Heijman E, Hijnen NM, Gruell H, TOPIM 2011, Les Houches, FR, Jan 2011.
‘Ultrasound induced drug delivery.’ Gruell H, TOPIM 2011, Les Houches, FR, Jan 2011.
‘Focused Ultrasound Induced Extravasation: In vivo SPECT/CT Imaging and Quantification.’ Sanches P, Rossin R, Bohmer M, Tiemann K, Gruell H, TOPIM 2011, Les Houches, FR, Jan 2011.
‘Focused Ultrasound mediated Targeted Drug Delivery.’ Moonen C, TOPIM 2011, Les Houches, FR, Jan 2011.
‘Mechanisms of sonoporation.’ Lentacker I, Geers B, De Smedt SC, 16th European Symposium on Ultrasound Contrast Imaging, Rotterdam (NL), Jan. 2011.
‘self-assemblED liposome-loaded microbubbles: the missing link for safe and efficient ultrasound triggered drug-delivery.’ Geers B, Lentacker I, Sanders N, Demeester J, Meairs S, De Smedt S, 16th European Symposium on Ultrasound Contrast Imaging, Rotterdam (NL), Jan. 2011.
‘Microbubble destruction: A key step for gene delivery with sonoporation.’ Escoffre JM, Zeghimi A, Novell A, Bouakaz A, 16th European Symposium on Ultrasound Contrast Imaging, Rotterdam (NL), Jan. 2011.
‘Optical Characterization of Individual Liposome Loaded Microbubbles.’ Y. Luan, 16th European Symposium on Ultrasound Contrast Imaging, Rotterdam (NL), Jan. 2011.
‘Drug- and gene- delivery in cardiovascular and tumor models.’ Muehlmeister M, Tiemann K, 16th European Symposium on Ultrasound Contrast Imaging, Rotterdam (NL), Jan. 2011.
‘Lipid distribution and viscosity of coated microbubbles.’ Kooiman K, Emmer M, Kokhuis TJA, Bosch JG, de Gruiter HM, van Royen ME, van Cappellen WA, Houtsmuller AB, van der Steen AFW, de Jong N, IEEE International Ultrasonics Symposium, San Diego (USA), Oct 2010.
‘Enhanced gene transfection using ultrasound and Vevo Micromarker microbubbles.’ Piron J, Escoffre JM, Kaddur K, Novell A, Bouakaz A, IEEE International Ultrasonics Symposium, San Diego (USA), Oct 2010.
‘Design principles of thermosensitive liposomes for MRI guided HIFU triggered anti-cancer drug delivery.’ Tejera-Garcia R, Zamotin V, Kinnunen PKJ, MRgFUS symposium, Oct 2010, Virginia, USA
‘Temperature sensitive liposomes for ultrasound-induced drug delivery under MRI guidance: in vitro and in vivo results.’ Heijman E, de Smet M, Hijnen N, Langereis S, Gruell, MRgFUS symposium, Oct 2010, Virginia, USA
‘Focused Ultrasound Mediated Targeted Drug Delivery.’ Moonnen C, MRgFUS symposium, Oct 2010, Virginia, USA
‘Tumor hyperthermia and ablation in small animals using a clinical MR-HIFU system.’ Hijnen N, Heijman E, Kohler M, Ylihautala M, Gruell H, MRgFUS symposium, Oct 2010, Virginia, USA
‘Image Guided Ultrasound mediated Drug Delivery: Sonodrugs Update.’ Seip R, Bohmer M, Gruell H, Steinbach O, Vulto S, ICUS Bubble conference, Chicago, Sept 2010
‘Ultrasound-mediated drug delivery: evaluate correspondence of macroscopic fluorescence imaging patern with acoustical properties of the transducer.’ Lepetit-Coiffe M, Yudina A, Poujol C, Lourenco de Oliveira P, Couillaud F, Moonen CTW, World Molecular Imaging Conference, Kyoto (JP), sep 2010
‘Long-lasting effect of ultrasound on cell membrane permeability: application to 2-step intracellular small-molecule delivery system using thermosensitive liposomes and cavitation’, Yudina A, Lepetit-Coiffe M, de Smet M, Langereis S, Gruell H, Moonen C, World Molecular Imaging Conference, Kyoto (JP), sep 2010
‘Temperature sensitive Liposomes for Ultrasound-induced Drug Delivery under MRI Guidance’, Gruell H, de Smet M, Hijnen N, Heijman E, Keupp J, Langereis S, World Molecular Imaging Conference, Kyoto (JP), sep 2010
‘In Vivo SPECT/CT Imaging of Focused Ultrasound Induced Extravasation’, Gruell H, Sanches, P Rossin R, Bohmer M, Tiemann K, World Molecular Imaging Conference, Kyoto (JP), sep 2010
‘Controlled Drug Delivery under Image Guidance’, Gruell H, 5th European Molecular Imaging Meeting, Warsaw, (PL), May 2010.
‘Evaluation of the Temporal Window for Drug Delivery Following Ultrasound Mediated Membrane Permeability Enhancement’, Yudina A, Lepetit-Coiffé M, Moonen CTW, 15th European Molecular Imaging Meeting, Warsaw, (PL), May 2010.
‘Focused Ultrasound and microbubbles for enhanced extravasation’, Bohmer MR, Chlon CHT, Raju BI, Chin CT, Shevchenko T, Klibanov A, 11th European symposum on controlled drug delivery, Egmond-aan-zee (NL), April 2010.
‘Adeno-associated virus loaded microbubbles as a tool for targeted gene delivery’, Geers B, Lentacker I, Alonso A, Meairs S, Demeester J, De Smedt SC, Sanders NN, 11th European symposum on controlled drug delivery, Egmond-aan-zee (NL), April 2010.
‘Ultrasound responsive doxorubicin-loaded microbubbles; towards an easy applicable drug delivery platform’, Geers B, Lentacker I, Cool S, Demeester J, Stefaan C. De Smedt, Niek N. Sanders, 11th European symposum on controlled drug delivery, Egmond-aan-zee (NL), April 2010.
‘Tumor Cell killing efficiency of doxorubicin loaded microbubbles after ultrasound exposure’ Lentacker I, Geers B, Demeester J, De Smedt SC, Sanders NN, 11th European symposum on controlled drug delivery, Egmond-aan-zee (NL), April 2010.
‘HIFU-mediated doxorubicin release from temperature-sensitive liposomes under MRI guidance’de Smet M, Langereis S, v.d. Molengraaf R, Heijman E, Hijnen N, Gruell H, Biomedica2010 Summit, Aachen (DE), March 2010
‘Quantification of Ultrasound-mediated Local Drug Delivery with Nuclear Techniques;Sanches P, Rossin R, Bohmer M, Tiemann K, Nicolaij K, Gruell H, Biomedica2010 Summit, Aachen (DE), March 2010.
‘Temperature sensitive liposomes for drug delivery with MRI-HIFU’ de Smet M, Langereis S, van de Molengraaf R, Heijman E, Hijnen N, Gruell H, 2nd Annual Meeting of the ISMRM Benelux, Utrecht (NL), Jan. 2010.
‘SPECT/CT Imaging and Quantification of Focused Ultrasound Induced Extravasation’, Sanchez P, Rossin R, Bohmer M, Tiemann K, Grull H, 15th European Symposium on Ultrasound Contrast Imaging, Rotterdam (NL), Jan. 2010.
‘Experimental investigation of microbubble response to ultrasonic pulses used in therapeutic applications’, Mannaris C, Stylianou K, de Jong N, Averkiou M, 15th European Symposium on Ultrasound Contrast Imaging, Rotterdam (NL), Jan. 2010.
‘Tumor cell killing efficiency of doxorubicin-liposome loaded microbubbles after ultrasound exposure’, Lentacker I, Geers B, Demeester J, De Smedt SC, Sanders NN, 15th European Symposium on Ultrasound Contrast Imaging, Rotterdam (NL), Jan. 2010.
‘Drug uptake by endothelial cells through targeted microbubble sonoporation’, Kooiman K, Foppen-Harteveld M, de Jong N, 15th European Symposium on Ultrasound Contrast Imaging, Rotterdam (NL), Jan. 2010.
‘Enhancement of doxorubicin effect on cancer cell mortality with ultrasound and microbubbles’, Piron J, Novell A, Kaddur K, Bouakaz A, 15th European Symposium on Ultrasound Contrast Imaging, Rotterdam (NL), Jan. 2010.
‘Quantitative imaging of the US-mediated uptake of the intercalating probes by the tumor cells’, Yudina A, Lepetit-Coiffe M, Lourenco de Oliveira P, Deckers R, Couillaud F, Moonen CTW, World Molecular Imaging Conference, Montreal (CA), sep 2009
‘TOTO-3 as a smart probe for the assesment of ultrasound-mediated local drug delivery in vivo’, Yudina A, Deckers R, Debeissat C, Moonen CTW, World Molecular Imaging Conference, Montreal (CA), sep 2009
‘Temperature-controlled US-mediated intracellular delivery of a fluorescent cell-impermeant model drug using temperature sensitive liposomes and cavitation’, de Smet M, Yudina A, Lepetit-Coiffe M, Langereis S, Deckers R, Grull H, Moonen C, World Molecular Imaging Conference, Montreal (CA), sep 2009
‘Magnetic Resonance-guided Imaging of Temperature Induced Drug Delivery’, Langereis S, de Smet M, Keupp J, Heijman E, Gruell H, World Molecular Imaging Conference, Montreal (CA), sep 2009
‘Binding force of targeted microbubbles measured by ultrasound radiation force’, Sugiura T, Kooiman K, Emmer M, Vos HJ, de Jong N, van Wamel A, World Molecular Imaging Conference, Montreal (CA), sep 2009
‘Sonoporation induced drug uptake by endothelial cells with ultrasound and CD31-targeted microbubbles’, Kooiman K, Foppen-Harteveld M, de Jong N, World Molecular Imaging Conference, Montreal (CA), sep 2009
‘Correlation of ultrasound-mediated drug delivery with acoustical properties of the transducer by macroscopic fluorescence imaging’, Lepetit-Coiffe M, Yudina A, Lourenco de Oliveira P, Decker R, Couillaud F, Moonen CTW,ISTU, Aix-en-Provence (FR), sep 2009
‘Enhancement of doxorubicin effect on cancer cell mortality with ultrasound and microbubbles’, Piron J, Kaddur K, Bouakaz A, ISTU, Aix-en-Provence (FR), sep 2009

Sonodrugs Poster

Poster

Image-Controlled Ultrasound-Induced Drug Delivery
Mission Consortium Press Release & Publications Vacancies Links Events To partner area Disclaimer NMP-2007-4.0-4	Sonodrugs Press Coverages: 07-02-2011 Philips and Eindhoven University of Technology measure and visualize local chemotherapy delivery to tumors. 18-01-2011 Hartkwalen te lijf met ‘dansende’ bellen. 29-01-2009 Nanobiotix enters into collaboration with ‘SonoDrugs’ consortium 28-01-2009 Philips leads European ‘SonoDrugs’ project to develop image-guided localized drug delivery technologies Sonodrugs publications: Journals ‘Elucidating the Mechanisms Behind Sonoporation with Adeno-Associated Virus-Loaded Microbubbles.’ Geers B, Lentacker I, Alonso A, Sanders NN, Demeester J, Meairs S, De Smedt SC, Mol Pharm, 2011, Nov 4 [Epub ahead of print] abstract ‘Simultaneous T(1) measurements and proton resonance frequency shift based thermometry using variable flip angles. ’ Hey S, de Smet M, Stehning C, Gruell H, Keupp J, Moonen CT, Ries M, Magn Reson Med 2011, Nov 2 [Epub ahead of print] abstract ‘Ultrasound-mediated intracellular drug delivery using microbubbles and temperature-sensitive liposomes.’ Yudina A, de Smet M, Lepetit-Coiffe M, Langereis S, Van Ruijssevelt L, Smirnov P, Bouchaud V, Voisin P, Gruell H, Moonen CT, J Control Rel, 2011, 155, 442-448. abstract ‘Making unilamellar liposomes using focused ultrasound; Tejera-Garcia R, Ranjan, Zamotin V, Sood R, Kinnunen PK, Langmuir 2011, 27, 10088-10097. abstract ‘Rupture threshold characterization of polymer-shelled ultrasound contrast agents subjected to static overpressure.’ Chitnis PV, Lee P, Mamou J, Allen JS, Bohmer M, Ketterling JA, J Appl Phys. 2011, 109, 84906-8490610. abstract ‘A fluorescent chromophore TOTO-3 as a 'smart probe' for the assessment of ultrasound-mediated local drug delivery in vivo. ’ Deckers R, Yudina A, Cardoit LC, Moonen CT, Contrast Media Mol Imaging. 2011, 6, 267-274 abstract ‘Doxorubicin delivery into tumor cells with ultrasound and microbubbles.’ Escoffre JM, Piron J, Novell A, Bouakaz A, Mol Imaging Biol. Mol Pharm. 2011, 8, 799-806. abstract ‘Ultrasound & microbubbles for in vitro gene delivery. ’ Escoffre JM, Novell A, Zeghimi A, Bouakaz A, Drug Dev. Del. 2011, 11, 42-47 ‘Rupture threshold characterization of polymer-shelled ultrasound contrast agents subjected to static overpressure.’ Chitnis PV, Lee P, Mamou J, Allen JS, Bohmer M, Ketterling JA, J Appl Phys. 2011, 109, 84906-8490610. abstract ‘Evaluation of the Temporal Window for Drug Delivery Following Ultrasound-Mediated Membrane Permeability Enhancement.’ Yudina A, Lepetit-Coiffe M, Moonen CT, Mol Imaging Biol. Mol Imaging Biol. 2011, 13, 239-49. abstract ‘Self-assembled liposome-loaded microbubbles: the missing link for safe and efficient ultrasound triggered drug delivery.’Geers B, Lentacker I, Sanders NN, Demeester J, Meairs S, De Smedt Sc, J Control Rel. 2011, 152, 249-56 abstract ‘Magnetic resonance imaging of high intensity focused ultrasound mediated drug delivery from temperature sensitive liposomes; An in vivo proof-of-concept study. ’ de Smet M, Heijman E, Langereis S, Hijnen N, Gruell H, J Control Release. 2011, 150, 102-110. abstract ‘Cardioprotective effect of calcineurin inhibition in an animal model of renal disease.’ Di Marco GS, Reuter S, Kentrup D, Ting L, Ting L, Grabner A, Jacobi AM, Pavenstadt H, Baba HA, Tiemann K, Brand M, Eur Heart J. 2010 Dec 7. [Epub ahead of print]. abstract ‘Vascular infarction by subcutaneous application of tissue factor targeted to tumor vessels with NGR-peptides: activity and toxicity profile.’ Dreischaluck J, Schwoppe C, Spieker T, Kessler T, Tiemann K, Liersch R, Schliemann C, Kreuter M, Kolkmeyer A, Hintelmann H, Mesters RM, Berdel WE. Int J Oncol. 2010, 37, 1389-97. abstract ‘Ultrasound triggered, image guided, local drug delivery.’ Deckers R, Moonen CT, J. Controlled Rel., 2010, 148, 25-33. abstract ‘Focused ultrasound and microbubbles for enhanced extravasation.’ Bohmer MR, Chlon CH, Raju BI, Chin CT, Shevchenko T, Klibanov AL., J Control Rel. 2010, 148, 18-24 abstract ‘Indicator Dilution Models for the Quantification of Microvascular Blood Flow with Bolus Administration of Ultrasound Contrast’, Strouthos C, Lampaskis M, Averkiou M, IEEE Trans Ultrason Ferroelectr Freq Contr 2010, 57, 1296-310. abstract ‘Temperature-sensitive liposomes for doxorubicin delivery under MRI guidance’, de Smet M, Langereis S, den Bosch SV, Gruell H, J Control Release, 2010, 143, 120-7. abstract ‘Increasing the Endothelial Layer Permeability through Ultrasound-Activated Microbubbles’, Kooiman K, Emmer M, Foppen-Harteveld M, van Wamel A, de Jong N, IEEE Trans. Biomed. Eng. 2010, 57, 29-32. abstract ‘Design and Evaluation of Doxorubicin-containing Microbubbles for Ultrasound-triggered Doxorubicin Delivery: Cytotoxicity and Mechanisms Involved.’, Lentacker I, Geers B, Demeester J, De Smedt SC, Sanders NN., Mol Ther. 2010, 18, 101-108. abstract ‘Ultrasound triggered image guided therapy’, Bohmer M, Moonen C, de Jong N, Langereis S, Steinbach O, MEDICAMUNDI, 2010, 54, 40. journal ‘Drug loaded microbubbles design for ultrasound triggered delivery’ Lentacker I, Stefaan C. De Smedt SC, Sanders NN, Soft Matter 2009, 5, 2161-2170. ‘Ultrasound exposure of lipoplex loaded microbubbles facilitates direct cytoplasmic entry of the lipoplexes’, Lentacker I, Wang N, Vandenbroucke RE, Demeester J, De Smedt SC, Sanders NN, Mol. Pharm. 2009, 6, 457-467. abstract ‘Focused ultrasound-induced stimulation of microbubbles augments site-targeted engraftment of mesenchymal stem cells after acute myocardial infarction.’, Ghanem A, Steingen C, Brenig F, Funcke F, Bai ZY, Hall C, Chin CT, Nickenig G, Bloch W, Tiemann K, J Mol Cell Cardiol. 2009, 47, 411-8. abstract Conferences ‘Sonoporation of endothelial cells in vivo.’ Skachkov I, Kooiman K, Luan Y, van der Steen T, de Jong N, IEEE International Ultrasonics Symposium, Orlando (USA), Oct 2011 ‘Optical characterization of individual liposome loaded microbubbles.’ Luan Y, Faez T, Gelderblom EC, Skachkov I, Geers B, Lentacker I, van der Steen AFW, Versluis M, de Jong N,IEEE International Ultrasonics Symposium, Orlando (USA), Oct 2011 ‘Doxorubicin-liposomes loaded microbubbles for ultrasound-triggered doxorubicin delivery.’ Escoffre JM, Geers B, Lentacker I, Bouakaz A, IEEE International Ultrasonics Symposium, Orlando (USA), Oct 2011 ‘In-vitro evaluation of thermosensitive liposomes for high-intensity focused ultrasound-triggered doxorubicin delivery .’ Escoffre JM, Mannaris C, Efthymiou E, Novell A, Meyre M-E, Germain M, Averkiou M, Bouakaz A, IEEE International Ultrasonics Symposium, Orlando (USA), oct 2011 ‘Progress in image guided ultrasound mediated drug delivery in the European Union project Sonodrugs.’ Sio SF, ICUS Bubble conference, Chicago, Sept 2011 ‘Focused ultrasound mediated drug delivery in vitro and in vivo and the influence of short and long pulsing schemes on delivery efficacy. ’ Muehlmeister M, Tenbrinck D, McFarland RJ, McKeown KR, Matsunaga TO, Stypmann J, Seip R, Raju, BI, Tiemann K, World Moleculear Imaging Conference, San Diego (US), Sept 2011 ‘Temperature-controlled ultrasound-mediated intracellular delivery of cell-impermeant molecules: in vivo study. ’ Yudina A, Lepetit-Coiffe M, de Smet M, Langereis S, Lorenzato C, Gruell H, Moonen C, World Molecular Imaging Conference, San Diego (US), Sept 2011 ‘In vivo gene transfection mediated by focused ultrasound.’ Sanches P, Bohmer M, Tiemann K, Gruell H, World Molecular Imaging Conference, San Diego (US), Sept 2011 ‘Ultrasound mediated membrane permeability enhancement of C6 glioma cells: a preliminary viability study for evaluation of local drug delivery. ’ Van Ruijssevelt L, Smirnov P, Yudina A, Bouchaud V, Voisin P, Moonen C, World Molecular Imaging Conference, San Diego (US), Sept 2011 ‘Fabrication, Characterisation and Translational Applications.’ Lentacker I, Geers B, de Smedt SC, Muehlmeister M, Tiemann K, Luan Y, De Jong N, Bohmer M, Vulto S, Sio CF, First Annual Microbubble Symposium of the University of Leeds Microbubble Consortium, Leeds, July 2011 ‘A novel method to determine the lipid viscosity and distribution of coated microbubbles.’ Kooiman K, Emmer M, Kokhuis TJA, Bosch JG, de Gruiter HM, van Royen ME, van Cappellen WA, Houtsmuller AB, van der Steen AFW, de Jong N, First Annual Microbubble Symposium of the University of Leeds Microbubble Consortium, Leeds, July 2011 ‘Assessment of Ultrasound-Mediated Drug Delivery by Real-Time Imaging Using Fibered Confocal Fluorescence Microscopy.’ Derieppe M, Lepetit-Coiffe M, Yudina A, Denis de Senneville B, Roujol S, Moonen CTW, 6th European Molecular Imaging Meeting 2011 (EMIM ESMI), Leiden, NL, June 2011. ‘Real-Time Imaging of 2-step Ultrasound-Mediated Temperature-Controlled Drug Delivery using Fibered Confocal Fluorescence Microscopy.’ Yudina A, Lepetit-Coiffe M, Derieppe M, de Smet M, Langereis S, Gruell H, Moonen C, 6th European Molecular Imaging Meeting 2011 (EMIM ESMI), Leiden, NL, June 2011. ‘MR monitoring of HIFU-mediated local drug delivery with temperature sensitive liposomes.’ de Smet M, Langereis S, Heijman E, Hijnen N, Gruell H, 6th European Molecular Imaging Meeting 2011 (EMIM ESMI), Leiden, NL, June 2011 ‘Use of high intensity focused ultrasound for localized activation of thermosensitive liposomes for drug delivery.’ Mannaris C, Efthymiou E, Khokhlova VA, Ilin SA, Escoffre JM, Bouakaz A, Mathieu G, Averkiou MA, 161st Meeting of the Acoustical Society of America, Seattle, USA, May 2011. ‘Investigation of microbubble response to long ultrasonic pulses used in therapeutic applications.’ Mannaris C, Averkiou M, 161st Meeting of the Acoustical Society of America, Seattle, USA, May 2011. ‘Temperature-Induced Drug Delivery Using MR-Guided High Intensity Focused Ultrasound.’ Langereis S, de Smet M, Heijman E, Hijnen N, H. Gruell H, 28th Annual Meeting of the Society for Thermal Medicine, New Orleans, USA, May 2011. ‘HIFU-mediated local drug delivery under MR image guidance.’ de Smet M, Langereis S, Heijman E, Hijnen N, Gruell H, esho 2011 - 27h Annual Meeting of the European society for hyperthermic oncology, Arhus, DK, May 2011. ‘Thermosensitive magnetoliposomes for MRI-guided drug delivery.’ Meyre ME, Lorenzato C, Germain M, Smirnov P, Moonen C, Pottier A, Levy L, 4th European-Conference for Clinical Nanomedicine, Basel, CH, May 2011. ‘Parallel RF transmit based MRI technique for highly sensitive detection of Amide Proton Transfer in the human brain at 3T.’ Keupp J et al., ISMRM 2011, Montreal, CA, May 2011. ‘Temperature-induced drug delivery using MR-guided high intensity focused ultrasound.’ Langereis S, de Smet M, Heijman E, Hijnen N, Gruell H, 28th Annual Meeting of the Society for Thermal Medicine, New Orleans (USA), May 2011. ‘Local drug delivery with temperature senstive liposomes under MR image guidance.’ de Smet M, Langereis S, Heijman E, Hijnen NM, Gruell H, Biomedica2011 Summit, Eindhoven (NL), April 2011. ‘Ultrasound drug delivery: in vivo SPECT/CT imaging and quantification.’ Sanches P, Gruell H, Biomedica2011 Summit, Eindhoven (NL), April 2011. ‘High-intensity focused ultrasound-mediated doxorubicin delivery with thermosensitive liposomes.’ Escoffre JM, Mannaris C, Rio L, Meyre ME, Germain M, Averkiou M, Bouakaz A, International Symposium on Therapeutic Ultrasound, New York, USA, April 2011. ‘Self-assembled liposome loaded microbubbles.’Geers B, Lentacker I, Sanders NN, Demeester J, Meairs S, De Smedt SC, International Symposium on Therapeutic Ultrasound, New York, USA, April 2011. ‘Near-Field Heating of Volumetric MR-HIFU Hyperthermia.’ Kohler M; Mougenot C; Ylihautala M, International Symposium on Therapeutic Ultrasound, New York, USA, April 2011. ‘The use of contrast agents in cancer immunotherapy: the use of mRNA loaded microbubbles for transfection of dendritic cells.’ Dewitte H, De Temmerman M, De Smedt SC, Rejman J, Lentacker I, International Symposium on Therapeutic Ultrasound, New York, USA, April 2011. ‘Temperature-induced drug delivery under MR image guidance.’ de Smet M, Heijman E, Langereis S, Hijnen N, Gruell H, ISMRM Benelux, Jan 2011. ‘MRI-guided HIFU-mediated drug delivery to tumors with temperature-sensitive liposomes; de Smet M, S. Langereis S, E. Heijman E, Hijnen NM, Gruell H, TOPIM 2011, Les Houches, FR, Jan 2011. ‘Ultrasound induced drug delivery.’ Gruell H, TOPIM 2011, Les Houches, FR, Jan 2011. ‘Focused Ultrasound Induced Extravasation: In vivo SPECT/CT Imaging and Quantification.’ Sanches P, Rossin R, Bohmer M, Tiemann K, Gruell H, TOPIM 2011, Les Houches, FR, Jan 2011. ‘Focused Ultrasound mediated Targeted Drug Delivery.’ Moonen C, TOPIM 2011, Les Houches, FR, Jan 2011. ‘Mechanisms of sonoporation.’ Lentacker I, Geers B, De Smedt SC, 16th European Symposium on Ultrasound Contrast Imaging, Rotterdam (NL), Jan. 2011. ‘self-assemblED liposome-loaded microbubbles: the missing link for safe and efficient ultrasound triggered drug-delivery.’ Geers B, Lentacker I, Sanders N, Demeester J, Meairs S, De Smedt S, 16th European Symposium on Ultrasound Contrast Imaging, Rotterdam (NL), Jan. 2011. ‘Microbubble destruction: A key step for gene delivery with sonoporation.’ Escoffre JM, Zeghimi A, Novell A, Bouakaz A, 16th European Symposium on Ultrasound Contrast Imaging, Rotterdam (NL), Jan. 2011. ‘Optical Characterization of Individual Liposome Loaded Microbubbles.’ Y. Luan, 16th European Symposium on Ultrasound Contrast Imaging, Rotterdam (NL), Jan. 2011. ‘Drug- and gene- delivery in cardiovascular and tumor models.’ Muehlmeister M, Tiemann K, 16th European Symposium on Ultrasound Contrast Imaging, Rotterdam (NL), Jan. 2011. ‘Lipid distribution and viscosity of coated microbubbles.’ Kooiman K, Emmer M, Kokhuis TJA, Bosch JG, de Gruiter HM, van Royen ME, van Cappellen WA, Houtsmuller AB, van der Steen AFW, de Jong N, IEEE International Ultrasonics Symposium, San Diego (USA), Oct 2010. ‘Enhanced gene transfection using ultrasound and Vevo Micromarker microbubbles.’ Piron J, Escoffre JM, Kaddur K, Novell A, Bouakaz A, IEEE International Ultrasonics Symposium, San Diego (USA), Oct 2010. ‘Design principles of thermosensitive liposomes for MRI guided HIFU triggered anti-cancer drug delivery.’ Tejera-Garcia R, Zamotin V, Kinnunen PKJ, MRgFUS symposium, Oct 2010, Virginia, USA ‘Temperature sensitive liposomes for ultrasound-induced drug delivery under MRI guidance: in vitro and in vivo results.’ Heijman E, de Smet M, Hijnen N, Langereis S, Gruell, MRgFUS symposium, Oct 2010, Virginia, USA ‘Focused Ultrasound Mediated Targeted Drug Delivery.’ Moonnen C, MRgFUS symposium, Oct 2010, Virginia, USA ‘Tumor hyperthermia and ablation in small animals using a clinical MR-HIFU system.’ Hijnen N, Heijman E, Kohler M, Ylihautala M, Gruell H, MRgFUS symposium, Oct 2010, Virginia, USA ‘Image Guided Ultrasound mediated Drug Delivery: Sonodrugs Update.’ Seip R, Bohmer M, Gruell H, Steinbach O, Vulto S, ICUS Bubble conference, Chicago, Sept 2010 ‘Ultrasound-mediated drug delivery: evaluate correspondence of macroscopic fluorescence imaging patern with acoustical properties of the transducer.’ Lepetit-Coiffe M, Yudina A, Poujol C, Lourenco de Oliveira P, Couillaud F, Moonen CTW, World Molecular Imaging Conference, Kyoto (JP), sep 2010 ‘Long-lasting effect of ultrasound on cell membrane permeability: application to 2-step intracellular small-molecule delivery system using thermosensitive liposomes and cavitation’, Yudina A, Lepetit-Coiffe M, de Smet M, Langereis S, Gruell H, Moonen C, World Molecular Imaging Conference, Kyoto (JP), sep 2010 ‘Temperature sensitive Liposomes for Ultrasound-induced Drug Delivery under MRI Guidance’, Gruell H, de Smet M, Hijnen N, Heijman E, Keupp J, Langereis S, World Molecular Imaging Conference, Kyoto (JP), sep 2010 ‘In Vivo SPECT/CT Imaging of Focused Ultrasound Induced Extravasation’, Gruell H, Sanches, P Rossin R, Bohmer M, Tiemann K, World Molecular Imaging Conference, Kyoto (JP), sep 2010 ‘Controlled Drug Delivery under Image Guidance’, Gruell H, 5th European Molecular Imaging Meeting, Warsaw, (PL), May 2010. ‘Evaluation of the Temporal Window for Drug Delivery Following Ultrasound Mediated Membrane Permeability Enhancement’, Yudina A, Lepetit-Coiffé M, Moonen CTW, 15th European Molecular Imaging Meeting, Warsaw, (PL), May 2010. ‘Focused Ultrasound and microbubbles for enhanced extravasation’, Bohmer MR, Chlon CHT, Raju BI, Chin CT, Shevchenko T, Klibanov A, 11th European symposum on controlled drug delivery, Egmond-aan-zee (NL), April 2010. ‘Adeno-associated virus loaded microbubbles as a tool for targeted gene delivery’, Geers B, Lentacker I, Alonso A, Meairs S, Demeester J, De Smedt SC, Sanders NN, 11th European symposum on controlled drug delivery, Egmond-aan-zee (NL), April 2010. ‘Ultrasound responsive doxorubicin-loaded microbubbles; towards an easy applicable drug delivery platform’, Geers B, Lentacker I, Cool S, Demeester J, Stefaan C. De Smedt, Niek N. Sanders, 11th European symposum on controlled drug delivery, Egmond-aan-zee (NL), April 2010. ‘Tumor Cell killing efficiency of doxorubicin loaded microbubbles after ultrasound exposure’ Lentacker I, Geers B, Demeester J, De Smedt SC, Sanders NN, 11th European symposum on controlled drug delivery, Egmond-aan-zee (NL), April 2010. ‘HIFU-mediated doxorubicin release from temperature-sensitive liposomes under MRI guidance’de Smet M, Langereis S, v.d. Molengraaf R, Heijman E, Hijnen N, Gruell H, Biomedica2010 Summit, Aachen (DE), March 2010 ‘Quantification of Ultrasound-mediated Local Drug Delivery with Nuclear Techniques;Sanches P, Rossin R, Bohmer M, Tiemann K, Nicolaij K, Gruell H, Biomedica2010 Summit, Aachen (DE), March 2010. ‘Temperature sensitive liposomes for drug delivery with MRI-HIFU’ de Smet M, Langereis S, van de Molengraaf R, Heijman E, Hijnen N, Gruell H, 2nd Annual Meeting of the ISMRM Benelux, Utrecht (NL), Jan. 2010. ‘SPECT/CT Imaging and Quantification of Focused Ultrasound Induced Extravasation’, Sanchez P, Rossin R, Bohmer M, Tiemann K, Grull H, 15th European Symposium on Ultrasound Contrast Imaging, Rotterdam (NL), Jan. 2010. ‘Experimental investigation of microbubble response to ultrasonic pulses used in therapeutic applications’, Mannaris C, Stylianou K, de Jong N, Averkiou M, 15th European Symposium on Ultrasound Contrast Imaging, Rotterdam (NL), Jan. 2010. ‘Tumor cell killing efficiency of doxorubicin-liposome loaded microbubbles after ultrasound exposure’, Lentacker I, Geers B, Demeester J, De Smedt SC, Sanders NN, 15th European Symposium on Ultrasound Contrast Imaging, Rotterdam (NL), Jan. 2010. ‘Drug uptake by endothelial cells through targeted microbubble sonoporation’, Kooiman K, Foppen-Harteveld M, de Jong N, 15th European Symposium on Ultrasound Contrast Imaging, Rotterdam (NL), Jan. 2010. ‘Enhancement of doxorubicin effect on cancer cell mortality with ultrasound and microbubbles’, Piron J, Novell A, Kaddur K, Bouakaz A, 15th European Symposium on Ultrasound Contrast Imaging, Rotterdam (NL), Jan. 2010. ‘Quantitative imaging of the US-mediated uptake of the intercalating probes by the tumor cells’, Yudina A, Lepetit-Coiffe M, Lourenco de Oliveira P, Deckers R, Couillaud F, Moonen CTW, World Molecular Imaging Conference, Montreal (CA), sep 2009 ‘TOTO-3 as a smart probe for the assesment of ultrasound-mediated local drug delivery in vivo’, Yudina A, Deckers R, Debeissat C, Moonen CTW, World Molecular Imaging Conference, Montreal (CA), sep 2009 ‘Temperature-controlled US-mediated intracellular delivery of a fluorescent cell-impermeant model drug using temperature sensitive liposomes and cavitation’, de Smet M, Yudina A, Lepetit-Coiffe M, Langereis S, Deckers R, Grull H, Moonen C, World Molecular Imaging Conference, Montreal (CA), sep 2009 ‘Magnetic Resonance-guided Imaging of Temperature Induced Drug Delivery’, Langereis S, de Smet M, Keupp J, Heijman E, Gruell H, World Molecular Imaging Conference, Montreal (CA), sep 2009 ‘Binding force of targeted microbubbles measured by ultrasound radiation force’, Sugiura T, Kooiman K, Emmer M, Vos HJ, de Jong N, van Wamel A, World Molecular Imaging Conference, Montreal (CA), sep 2009 ‘Sonoporation induced drug uptake by endothelial cells with ultrasound and CD31-targeted microbubbles’, Kooiman K, Foppen-Harteveld M, de Jong N, World Molecular Imaging Conference, Montreal (CA), sep 2009 ‘Correlation of ultrasound-mediated drug delivery with acoustical properties of the transducer by macroscopic fluorescence imaging’, Lepetit-Coiffe M, Yudina A, Lourenco de Oliveira P, Decker R, Couillaud F, Moonen CTW,ISTU, Aix-en-Provence (FR), sep 2009 ‘Enhancement of doxorubicin effect on cancer cell mortality with ultrasound and microbubbles’, Piron J, Kaddur K, Bouakaz A, ISTU, Aix-en-Provence (FR), sep 2009 Sonodrugs Poster Poster
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